These metabolites are known to stimulate GLP-1 and PYY secretion and improve gut barrier function, processes that may enhance the metabolic efficacy of GLP-1 RA therapy when combined with dietary fiber enrichment ( The clinical relevance of such complementary approaches is highlighted by evidence showing that co-administration of probiotics, such as Limosilactobacillus fermentum GB102, with GLP-1RAs (e.g., dulaglutide) significantly enhances weight loss and attenuates weight regain after treatment cessation in obese mice ( While probiotics and prebiotics aim to reshape microbial communities and their metabolic activity, postbiotics offer an alternative strategy by directly delivering bioactive microbial products, particularly in individuals characterized by marked dysbiosis or reduced microbial diversity

When ultraviolet rays penetrate the skin and damage DNA, thymidine dinucleotide (pTpT) fragments from damaged DNA will trigger melanogenesis [26] and cause the melanocyte to produce melanosomes, which are then transferred by dendrites to the top layer of keratinocytes
This is the part of the record that most resembles conventional preclinical pharmacology, and it is the part worth citing when the question is whether the compound does anything at all in a living tissue
Sharma V, Kaur A, Singh TG