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Who should consider adding lipo C to semaglutide therapy? Patients losing more than 23 pounds weekly on semaglutide, those experiencing persistent afternoon fatigue despite adequate sleep, or those with elevated liver enzymes (ALT/AST above 40 U/L) during treatment are the strongest candidates for adding lipo C
Others have bacterial contamination or heavy metal residues
Side effects normally go away within 1 month of stopping semaglutide
Semaglutides introduction of a fatty acid side chain at position 26 Lys allows reversible binding to plasma albumin and reduces renal clearance, and substitution of amino acids at positions 8 and 34 with Aib and Arg avoids its degradation by DPP-4 and prevents fatty acid binding at the wrong site, resulting in a once-weekly dosing (Lau et al., 2015
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