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Using this same approach to examine the cytotoxic effects of PE treatment (Zhang et al., 2021), a 50 M PE dose was selected for subsequent experimental use (Figures 3C,D)
Consistently, elevated circulating IL-6 levels are associated with increased mortality risk and greater motor symptom severity in PD, reflecting a sustained TNF--driven inflammatory state [188]
However, complete symptom resolution often requires several weeks to months of consistent treatment
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