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At minimum: baseline IGF-1, fasting glucose, HbA1c, comprehensive metabolic panel, and a full hormone panel

In the context of DR, this leads to the phosphorylation of ERK1/2, increasing downstream expression of anti-apoptotic genes like BCL2 and reducing the activity of pro-apoptotic markers such as Caspase-3

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While each injection lasts for seven days, the long-term success of semaglutide builds gradually with ongoing use