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Some reversions, such as Arg242Tyr and Phe244Leu, substantially reduced activity on GD_M, whereas others, particularly in regions spanning residues 167 and 314439, maintained or improved activity (Supplementary Fig

109, 21, 125 The Panel's clinical experience reflected diverse approaches to effective pain management, ranging from primary management by the practicing urologist to use of a multidisciplinary team incorporating an anesthesia/pain specialist