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How sublingual tirzepatide fits into the broader GLP-1 landscape Sublingual tirzepatide does not exist in isolation
Patients start with 0.25 mg of semaglutide once a week
Due to tirzepatide's pharmacokinetic profile (peak concentration at approximately 24-48 hours and half-life of about 5 days), symptoms may persist for several days following a double dose, with effects potentially lasting longer than with shorter-acting GLP-1 receptor agonists
Patients often experience a catching or locking sensation, making it difficult to move the knee smoothly
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