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Skibicka KP (2013) The central GLP-1: implications for food and drug reward

Note: see Appendix for an abbreviated summary of strikingly limited head-to-head RCT evidence that exist at the time of this writing Matiegka defines FFM as bone + skeletal muscle + connective tissue + organs + water

[xiii] - Smyth JF, Bowman A, Perren T, et al

preconception planning is important for patients with Hashimoto's disease [1] [2] Severe GI disease : Use caution or avoid in patients with severe gastrointestinal disease, including gastroparesis [1] Renal function : Monitor for dehydration and renal impairment if significant gastrointestinal adverse events occur Medication interactions : Do not use concurrently with other GLP-1 receptor agonists Patients with Hashimoto's disease considering tirzepatide should undergo comprehensive evaluation by an endocrinologist or physician experienced in managing both thyroid disorders and obesity pharmacotherapy