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Biochemistry (Moscow), 78(3), 324334

Contrave Contraindications Absolute contraindications: Uncontrolled hypertension Seizure disorder or history of seizures Conditions that increase seizure risk (eating disorders with purging, alcohol withdrawal, benzodiazepine withdrawal) Current or recent use of MAO inhibitors (within 14 days) Current opioid use or opioid withdrawal Chronic opioid therapy (naltrexone will precipitate withdrawal) Pregnancy Known allergy to bupropion or naltrexone Relative contraindications/use with caution: History of eating disorders (bulimia, anorexia) Controlled hypertension (monitor closely) Bipolar disorder (risk of manic episodes) Hepatic impairment Renal impairment Medications to avoid: Opioid pain medications (naltrexone blocks their effect) MAO inhibitors Other bupropion products Medications that lower seizure threshold Semaglutide Contraindications Absolute contraindications: Personal or family history of medullary thyroid carcinoma (MTC) Multiple Endocrine Neoplasia syndrome type 2 (MEN2) Pregnancy Relative contraindications/use with caution: History of pancreatitis Severe gastrointestinal disease Diabetic retinopathy (may initially worsen with rapid glucose improvement) Fewer medication interactions: Adjust insulin/sulfonylureas if diabetic (hypoglycemia risk) No broad medication contraindications like Contrave has Contraindication Comparison Contrave has a longer list of contraindications, meaning more patients are ineligible for it than for semaglutide

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