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Animal toxicology studies extended longer
Second, the doses are small because the target is a high-affinity intracellular enzyme, not a receptor that needs saturating with milligrams of drug
But if you are losing weight consistently at your current dose with manageable side effects, there is no reason to increase
PubMed: 20219669 AOD 9604 Reduces Leptin Levels and Improves Leptin Sensitivity in High-Fat Diet Obese Rats animal Liu B, Duong T, Nusser J, et al
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