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Many commercial plans cover GLP-1s for obesity (often with prior auth requiring BMI 30 or 27 with comorbidities)
Patients in the semaglutide treatment arm of STEP 1 were more likely to be exposed to the medication at the full dose of 2.4 mg than those in SELECT
On the metabolic side, the 2016 weight-loss meta-analysis by Pooyandjoo (PMID 27335245) pooled nine randomized trials (n = 911) using roughly 1.8-2 g/day and reported a mean weight difference of 1.33 kg versus control real but modest, and the analysis noted the effect shrank over time
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