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The chief drugs implicated in druginduced melanosis are the antimalarials, including chloroquine, hydroxychloroquine, and quinacrine (Figure 515)

A meta-analysis produces a weighted summary result, in which more weight is given to larger studies

Japanese formulations are supported by extensive research and clinical trials, reinforcing their credibility as dermatologist-recommended options for skin brightening supplements worldwide

Individuals with pre-existing liver disease, hepatitis B or C, acetaminophen-induced liver injury history, or conditions causing glutathione depletion face substantially elevated overdose risk at standard doses