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The Phase 2 trial did include lower-dose groups (1mg, 4mg, 8mg), all of which showed meaningful weight loss, just less than the 12mg group
A systematic review has showed that a 5%10% weight reduction improves cardiometabolic parameters, including BP, blood glucose level and dyslipidemia (32)
About 4 in 10 patients had a shifted implantation window (the best time for the uterus to receive an embryo)
But nothing universal yet
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