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L-carnitine attenuates cardiac dysfunction by ischemic insults through Akt signaling pathway
Even if they get to the epithelium, they tend to have poor permeability, usually resulting in less than 1 percent bioavailability (the proportion of a drug that enters the circulatory system when introduced into the body, thereby having an active effect)
Persistent cellular damage provokes an inflammatory response that recruits innate immune cells (particularly macrophages) to the site of injury and elicits the release of pro-fibrotic factors, such as transforming growth factor (TGF-) and -smooth muscle actin (-SMA) [13]
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