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The long half-life (approximately five days) maintains stable blood levels with weekly dosing
Further, rats treated with ALCAR had high expression of ATF3 and S100 in the distal nerve tissues of the CN extrusion site
As illustrated by the GLP-1 experience, such limitations can delay translation by decades without invalidating the underlying biology ( Underexploration, as defined here, therefore reflects historical and technological context rather than intrinsic therapeutic inadequacy
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