Start your intake GLP-1 Medications and Pregnancy: What the Evidence Shows Animal reproduction studies on semaglutide and tirzepatide have not shown direct fetal harm at therapeutic doses, but human pregnancy data remains limited because these drugs were developed for diabetes and weight management in non-pregnant populations
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The main findings from the pooled population analysis were as follows: (1) GLP-1RAs were associated with an increased rate of pre-procedural GI symptoms (nausea, vomiting, dyspepsia, abdominal distension) compared to control, (2) GLP-1RA use resulted in an expressive increase in RGC compared to the control, (3) GLP-1RAs improved glycemic control and decreased the rate of rescue insulin administration compared to control, and (4) there was no significant difference between GLP-1RAs and control related to the rates of perioperative hypo or hyperglycemia, postoperative inotropic support, PONV, atrial fibrillation, and 30-day mortality
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