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All mice received 2 days of 10 mL/kg body weight sterile saline subcutaneous injections before beginning the treatment phase to allow for acclimation to the handling and stress associated with injections

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To explore the mechanism by which pasireotide acts on intestinal L-cells, we investigated the impact of DCA, or a nutrient mimicking our daily meals, on GLP-1 secretion from GLUTag cells