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As hypoxia results in upregulation of CD39 and CD73, increased tumor perfusion may also abrogate PKA-mediated immune suppression through reducing adenosine production in the TME (161)

Accumulating evidence indicates that GLP-1 receptor agonists influence feeding behavior through central neural pathways that also regulate compulsive and reward-driven actions

Since the heart cannot produce carnitine [284], it relies on uptake from the circulation [285], which explains the cause of cardiomyopathy in patients with primary carnitine deficiency

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