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(2019a) found higher surface expression of B7-H4, a B7 family molecule, was correlated with higher mature DC (CD11c+HLA-DRhigh) infiltration in EOC patient samples, which may be associated with increased expression of CXCL17, a monocyte and DC chemoattractant in those tumors
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Interestingly, unmodified itaconate did not elevate intracellular Nrf2 levels as significantly as 4-OI, potentially because its reactivity is insufficient to trigger KEAP1-NRF2-mediated stress responses in the absence of additional inflammatory stimuli [31]
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