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This material is intended strictly for laboratory investigation and analytical use
For me, learning about this was interesting because it explained why controlling hunger isnt just about willpower but also about how your body responds to food
Replacement of Sec46 by a cysteine or mutation of any of the 3 other amino acids of the catalytic site results in an abrogation or a diminution of GPX4 enzymatic activity [1]
However, Januvia requires dose adjustment in patients with renal impairment specifically, a reduction to 50 mg for eGFR 3044 and 25 mg for eGFR below 30
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