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Handling technique is a stability question too: diluent is directed down the inside wall of the vial rather than onto the powder pellet, and the vial is swirled gently rather than shaken, because agitation can shear peptide bonds
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Dasatinib has shown antifibrotic effects in keloid fibroblasts and xenotransplant keloid tissue in mice through the selective clearance of senescent cells and modulation of SASP, implying that dasatinib can be possibly used for senolytic treatment of keloids 15
This is a crucial part of any regenerative medicine plan, and getting it right from the start makes all the difference
