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But the specific synergy remains theoretical
In their Standards of Care published in December 2025, the ADA recommends a GLP-1 receptor agonist with demonstrated benefits in MASH or a dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist with potential benefits in MASH for glycaemic management in people with type 2 diabetes, MASLD and overweight or obesity [23]
The two effects partially cancel out, and many patients report less prednisone-related weight gain when they're already on Zepbound
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