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However, the largest Phase IIb trial involving 536 subjects failed to demonstrate statistically significant weight loss compared to placebo at the primary 12-week endpoint, leading Metabolic Pharmaceuticals to terminate development in 2007

Its crucial to administer under medical supervision , especially when MIC injections are part of a broader weight loss protocol involving dietary changes or pharmacological agents

Both effects operate through pathways that appear independent of the canonical growth hormone receptor

However, the underlying cause of the deficiency must also be addressed in order to prevent relapse and further complications