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Evidence-based pharmacotherapy where appropriate
Early optimism in the use of GLP-1 therapies for Parkinsons disease has been tempered by the recent failure of a Phase III exenatide trial which did not show any benefits of slowing Parkinsons progression 10
In addition, semaglutide causes central c-Fos activation in eleven brain regions, including secondary regions devoid of direct GLP-1R interaction and portions of the hindbrain that are directly targeted by the drug
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