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Notably, MCP-1, also known as chemokine ligand 2 (CCL2), plays a pivotal role in promoting BBB instability by facilitating the recruitment of monocytes/Ms into CNS compartment and contributing to the reorganization of TJ and the actin cytoskeleton (Stamatovic et al., 2003)

The AAY linker was employed between CTL epitopes to facilitate proteasomal cleavage and efficient MHC class I presentation, while the GPGPG linker was used between HTL epitopes to preserve epitope integrity and promote effective MHC class II processing

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Patients start seeing results of the glutathione injections after at least 3weeks of the treatment