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Those who were already treated with an additional glucose-lowering drug (or several) at the beginning of combination therapy were included if (and when) the additional medication was halted and the individual thus received only a combination of metformin and GLP-1 RA or metformin and DPP-4i treatment

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Wegovy keeps its preferred status

Ongoing research suffers certain challenges like scalability, bulk manufacturing, regulatory concerns, and patient compliance in the real world to ensure nano-lipid-based formulation can achieve extensive clinical approval