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We also observed that mean enrichment of a substrate decreases monotonically with increasing Hamming distance to procaspase-1, consistent with our hypothesis that cleavage activity on single-residue substitutions is predictive of cleavage activity on higher-order combinations of substitutions (Supplementary Fig

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While not required, a calorie deficit with adequate protein (0.7 to 1.0 grams per pound of goal weight) produces best results

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