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doi: 10.1016/j.peptides.2019.170184 131 ParthsarathyVHlscherC

The titration schedule tested across all trials was: Weeks 1-4: 2.5 mg once weekly Weeks 5-8: 5 mg once weekly Weeks 9-12: 7.5 mg once weekly (optional step) Weeks 13-16: 10 mg once weekly Weeks 17-20: 12.5 mg once weekly (optional step) Weeks 21+: 15 mg once weekly (maximum approved dose) No trial tested 1.25 mg twice weekly, 2.5 mg twice weekly, or any other split-dose protocol

While GLP-1 medications may seem relatively new to the market, theyve actually been used for the treatment of Type 2 diabetes since 2005, when Byetta became the first FDA-approved GLP-1 medication

If an SNP did not meet the Affymetrix prescribed QC thresholds in a given batch, it was set to missing in all individuals from that batch