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The selectivity index of the glutathione-epothilone conjugate at 1:2 and 1:4 mM was about 5.76.1, compared to 1.92.6 of epothilone as control

The functional distinction between the enzymes terminal extensions is further demonstrated by structural analyses: the N-terminal extension seems to maximize substrate binding in alkaline environments through better cavity interactions and structural stabilization, whereas the C-terminal extension improves acid tolerance

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C.ChenJ.MiaoC.et al (2006)