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GHK-Cu is a copper-binding peptide that up-regulates collagen and elastin synthesis while down-modulating matrix metalloproteinases (MMPs), driving skin remodeling and connective-tissue repair
The discrepancy in effectors (AKT) phosphorylation and target genes (MyHC-S, MAFbx, and MuRF1) expression between EE/ICA and IGF-1 treatment may also hints for the application of different up-stream transducers by the two molecules
Until such evidence matures, the clinical use of nutraceuticals should remain an adjunctnot a replacementfor conventional therapy, and always under the supervision of an oncology care team
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