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Over time, linking organ-on-chip data, in silico digestion models and AI-based hazard prediction into a single safety-by-design pipeline would move nanoencapsulation from case-by-case evaluations toward more systematic, evidence-based development

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revealed the grievous connection between oxidative stress, pyroptosis, inflammation response, and xenobiotic metabolism in the myocardium of TMT-treated rats by String database analyzing the proteome interaction protein [206]

Accordingly, we have distinguished in the discussion between loci with known roles in ocular function or glaucoma-relevant pathways and those whose potential involvement is based on pleiotropic effects or shared molecular mechanisms