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Obesity : Excess body weight is associated with metabolic changes that increase urinary excretion of calcium, oxalate, and uric acid, all of which contribute to stone formation

33 Aroda, V.R., et al., Long-term Metformin Use and Vitamin B12 Deficiency in the Diabetes Prevention Program Outcomes Study

Incidence of the composite endpoint of myocardial infarction, coronary revascularization, hospitalization for heart failure, stroke or cardiovascular death was lower in the intensive treatment group (HR 0.88, 95% CI 0.780.99), with no interaction observed based on diabetes status or age

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