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Once both substrates are bound at the enzyme's active site, the monomeric GST interacts with another substrate-bound GST monomer and catalyzes a disulphide bridge between the two glutathione molecules

Concussion treatment supplements that are known to improve BDNF production and attenuate the inflammatory cascade include: Vitamin D Vitamin D is neuroprotective it promotes the production of heat shock proteins, which help maintain neurons integrity and support brain cell survival after a brain injury

Coscia L, Causa P, Giuliani E, Nunziata A

[3] The N-terminal domain contains the glutathione-binding site and is a highly conserved region among all GSTs