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The key difference is that semaglutide operates at much lower milligram doses than tirzepatide
Conclusions/interpretation At current prices, use of SGLT2is, but not GLP-1 RAs, would be cost-effective when considering only their cardiovascular and kidney disease benefits for people with type 2 diabetes
Furthermore, the results of some secondary analyses should be interpreted with caution due to wide confidence intervals stemming from the rarity of the outcomes
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