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Across preclinical studies, Epitalon has shown: Telomerase activation and telomere extension: Via TRAP assays and fibroblast lifespan extension beyond the Hayflick limit Epigenetic remodeling: Reversal of chromatin aging, histone modulation, and gene promoter binding Redox homeostasis: Increased antioxidant enzymes (SOD, NQO1, catalase) and reduced ROS, lipid peroxidation, and DNA damage Circadian restoration: Upregulation of AANAT/pCREB, normalized melatonin and cortisol rhythms, and clock gene modulation in humans Cancer risk reduction: Reduced tumor multiplicity and delayed onset in HER-2/neu and colon cancer models
Curr Opin Clin Nutr Metab Care
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In published preclinical research, BPC-157 has been administered at doses ranging from 6 to 50 micrograms per kilogram body weight in animal models, with most tissue-repair and gastric-protection protocols using 10 to 20 mcg/kg once or twice daily (PMID 21030672, PMID 32558293, PMID 38980576)
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