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Back in 1980, studies indicated that SystemX c was capable of transferring cystine into cells and simultaneously exchanging glutamate at a ratio of 1:1 in an ATP-independent manner (Bannai and Kitamura, 1980
Non-randomised studies were included as they primarily address pharmacokinetic, neuroimaging, and mechanistic endpoints, such as central nervous system bioavailability and glutathione redox status, which are often not adequately evaluated in the RCT studies
To minimize the high-energy, high-shear regime, power was distributed through an upsized impeller diameter designed for larger working volumes
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