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Current literature emphasizes mechanistic exploration within controlled experimental models rather than definitive biological outcomes

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However, sulforaphane co-administration blunts ROS elevation through increased expression of the antioxidant scavenger, glutathione, thereby preventing neuronal cell death (Sandouka and Shekh-Ahmad, 2021)

Overexpression of human hepsin in adult mice with AAV administration For the APAP susceptibility test, mice were made to overexpress human hepsin in the liver through transduction with 2.5 10 10 viral genome (vg) per mouse of AAV-hHPN WT /hHPN RS /EGFP via retro-orbital injection