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Rapid weight loss without adequate protein leads to muscle loss, which slows metabolism and creates the "skinny fat" outcome where the scale looks good but body composition tells a disappointing story
J Biol Chem 278:82798285 Kang G, Chepurny OG, Rindler MJ, Collis L, Chepurny Z, Li WH, Harbeck M, Roe MW, Holz GG (2005) A cAMP and Ca 2+ coincidence detector in support of Ca 2+ -induced Ca 2+ release in mouse pancreatic cells
Hossain, M
This is why clinicians should encourage realistic expectations and ongoing behavior support
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