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Glucagon is also involved in acutely regulating glucose homeostasis and administration of pharmacological doses of glucagon in animal models for diabetes or obesity has demonstrated regulatory effects on lipid metabolism, energy expenditure, and food intake ( The GLP-1/glucagon agonist cotadutide (MEDI0382) is the compound of this dual-receptor agonist class that is the most advanced in clinical development
Further evidence demonstrates that patients with diabetes mellitus display increased atrophy in the hippocampus and amygdala compared to non-diabetic individuals, an effect not explained by increased vascular morbidity [101]
It highlights the peptides ability to target stubborn fat through enhanced fat metabolism, including stimulating lipolysis and inhibiting fat synthesis, while preserving lean muscle mass
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