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The reasons why different subtypes of HDACs have distinct effect on epilepsy are possibly due to impact on different downstream target molecules and neural circuits across distinct brain regions
Trompier D, Chang XB, Barattin R, du Moulinet DHardemare A, Di Pietro A, Baubichon-Cortay H
Folate: metabolism, genes, polymorphisms and the associated diseases
In clinical trial design, a composite endpoint approach used in AMD research could be adopted to evaluate both seizure frequency (primary endpoint) and changes in SWI iron signals (secondary endpoint), providing more comprehensive evidence for the study of ferroptosis mechanisms
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