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Meanwhile, our results showed that CENPT bound to GCLC 213-424aa, which domain was also required for GCLM binding
Notably, emerging evidence reveals that HIF-1 transcriptionally activates heat shock factor 1 (HSF1), the master regulator of the heat shock response [56, 57]
Collectively, these findings indicate that reduced adipocyte mitochondrial CI activity during obesity is a key driver of visceral WAT metabolic dysfunction and subsequent systemic impairment in metabolic health
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