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A more recent 2018 review by Pickart and Margolina in the International Journal of Molecular Sciences documented GHK-Cu's influence on the expression of more than 4,000 human genes related to tissue remodeling, antioxidant defense, and anti-inflammatory signaling an observation that positions GHK-Cu as a broad-spectrum tissue-regulatory signal rather than a compound with a single mechanism

These findings provide mechanistic evidence for LPS directly stimulating ovarian local androgen excess, suggesting that chronic low-grade inflammation may be an important contributor to hyperandrogenemia in PCOS (49)

J.PirmohamedM.et al (1998)

Lisowska A, Knapp M, Tyciska A, Motybel E, Kamiski K, wicki P, et al