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This is where carnitine comes into play, Fatty acids cannot freely diffuse into the mitochondria, so they must hook up with carnitine in order to be transported into the mitochondria via a specialized biochemical process

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Altered acylcarnitines, such as palmitoyl-L-carnitine, disrupt energy metabolism and beta-oxidation, leading to mitochondrial fragmentation and increased cytosolic calcium [4345]

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