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Furthermore, a cohort study revealed that the majority of patients experienced a remarkable 5-10% reduction in weight after six months, with some achieving an astounding 20% or more
Further increases to 1 mg or 2 mg should only occur after at least four weeks at each dose level, allowing the body to adapt to the medication's effects
Long-Term Safety: What We Know and Don't Know What We Know (From TRIUMPH-4 and TRIUMPH-1) Up to 80 weeks of data: Side effects improve significantly after dose escalation (first 16 weeks hardest) No unexpected safety signals in either trial Dysesthesia doesn't worsen over time (stable) Discontinuation rates stabilize (most who stop do so in first 24 weeks) No deaths attributed to retatrutide in any completed trial TRIUMPH-1 104-week extension shows continued weight loss without new safety signals What We Don't Know Yet Longer-term questions (need 25+ years data): Does dysesthesia resolve completely if medication stopped
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