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One particular study suggested that the mechanism in which glutathione switches from eumelanin to pheomelanin production contributed to an individuals risk of acquiring skin cancers brought about by sun exposure
It also helps to prevent the activation of tyrosinase (the enzyme that helps produce more melanin) by reducing free radicals that can activate it and cause an increase in melanin production
That said, most published studies have used injection methods, and oral bioavailability in humans has not been clinically established
The authors administered oral Dihexa to APP/PS1 transgenic mice (a standard amyloidopathy model of Alzheimers disease) and showed that brain AngIV levels were elevated relative to wild-type after Dihexa administration, that spatial learning and memory were restored on Morris water maze testing, that hippocampal neuronal density and synaptophysin protein expression were preserved, that astrocyte and microglial activation were reduced, and that pro-inflammatory cytokines (IL-1, TNF-) decreased while anti-inflammatory IL-10 increased
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