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That doesn't mean every oral-capsule purchase is wasted it means the published pharmacology gives no support to expecting the mouse-data effects from oral product
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Mechanistic studies would be strengthened by isoform-specific NOS experiments, FAK or paxillin pathway inhibition, VEGFR2 pathway modulation, direct measurement of endothelial and fibroblast markers, and rescue experiments that test whether blocking one pathway prevents downstream effects
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