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Engagement of NTS Glu8.2 Calcr/Prlh neurons by cagrilintide in rats but not in mice To identify cellular mediators of cagrilintide action, we used expression of the immediate early gene Fos and its downstream target genes (the Fos regulon) as a transcriptional proxy for neuronal activation

While singly-housed animals may experience stress that impacts metabolism, body weight, and adiposity 65,66,67,68,69 , the singly-housed animals in this study were treated identically (to the best of the experimenters ability) to minimize and equalize stress across all animals and reduce confounding variables

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