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GLP-1 receptor agonist medications, which well call GLP-1s or GLP-1 medications in this article, mimic the natural GLP-1 hormone and bind to GLP-1 receptors in the brain

A double-blind trial of a glucomannan, inulin, and psyllium blend reported a 4.9 percent treatment difference over 180 days, but with a 74.6 percent rate of (mostly mild and transient) gastrointestinal adverse events versus none on placebo, which underlines that GI tolerability, driven by viscosity and fermentation, is the central fiber formulation challenge [5]