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However, in controlled clinical studies in adults (n = 3,890) and a controlled clinical study in pediatric patients (n = 349), subgroup analyses based on age, race, BMI and gender did not show differences in safety and efficacy between insulin glargine and NPH insulin [see Clinical Studies (14)]

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In the SURMOUNT-1 trial, published in the New England Journal of Medicine , participants without diabetes but with obesity received tirzepatide at varying doses (5 mg, 10 mg, or 15 mg weekly) or placebo, alongside lifestyle interventions