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Other cancer subtypes Similarly, the invasion potential of pituitary tumors and endometrial carcinomas was linked to reduction of GSTP1 expression and methylation frequency, indicating that epigenetically mediated down-regulation of GSTP1 expression may also contribute to aggressive pituitary tumor behavior ( PATHOLOGICAL ALTERATIONS OF GSTP1 METHYLATION PATTERNS Beyond DNA hypermethylation, which was the first epigenetic alteration to be discovered as an influencing factor for GSTP1 expression, histone modifications were discovered in the early 2000 s to play a regulating role in GSTP1 expression