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Results Development of the secreted Exe4 peptide-coding gene To develop a one-shot in vivo genome editing-based therapy for DIO and pre-diabetes, we targeted the liver due to its large size and ease of transduction, anticipating effective therapeutic peptide/protein production and secretion following successful genome editing (Fig
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Those scenarios could lead to starting a different weekly GLP-1 agonist, such as Mounjaro (tirzepatide), Zepbound (tirzepatide), or Trulicity (dulaglutide), about one week after the last dose of Ozempic
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